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In order to investigate specifically the role of mTORC1, we determined Exendin-4 effects on glucose consumption and uptake under inhibition of mTORC1 by Rapamycin, a compound that does not inhibit mTORC2 at the concentration tested (100 nM) (Fig

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We don't know the exact mechanisms yet of how these medications influence alcohol consumption, but our guess is that GLP-1 drugs can reduce the release of dopamine in the brain's motivation center, making previously rewarding behaviors, like over-drinking, less enjoyable, says Michelle Cardel, Ph.D., M.S., RD, chief nutrition officer at WeightWatchers

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